Application of Diffusion Weighted Imaging in Pathological Grading/Typing and Clinical Staging of 95 Cases of Cervical Adenocarcinoma / 中国医学科学院学报

Objective To investigate the correlations of diffusion weighted imaging (DWI) with pathological grading,typing and clinical staging of cervical adenocarcinoma. Methods The data of 95 patients with cervical adenocarcinoma from May 2011 to February 2018 in Cancer Hospital Chinese Academy of Medical Sciences were collected for retrospective analysis.Before treatment,conventional MRI and DWI (b=0,800 s/mm2) were performed,and the apparent diffusion coefficient (ADC) value of cervical adenocarcinoma was measured.The ADC values were compared among different pathological grades,types,and clinical stages. Results The mean ADC value was (1.00±0.25)×10-3 mm2/s in the poorly differentiation group,(1.09±0.25)×10-3 mm2/s in the moderately differentiation group,and (1.22±0.20)×10-3 mm2/s in the well differentiation group,which showed significant difference between the poorly and well differentiation groups (P=0.002).The mean ADC values were (1.04±0.24) ×10-3 mm2/s and (1.21±0.26)×10-3 mm2/s in the endocervical adenocarcinoma (usual type) group and mucinous carcinoma group,respectively,which showed significant difference (P=0.005). Conclusions The worse differentiation of cervical adenocarcinoma corresponded to the lower ADC value.The ADC value of mucinous carcinoma was higher than that of endocervical adenocarcinoma (usual type).

Application of organic fluorescent probe-assisted near infrared fluorescence imaging in cervical cancer diagnosis / 生物工程学报

Fluorescence imaging has been widely used in the fields of biomedicine and clinical diagnosis. Compared with traditional fluorescence imaging in the visible spectral region (400-760 nm), near-infrared (NIR, 700-1 700 nm) fluorescence imaging is more helpful to improve the signal-to-noise ratio and the sensitivity of imaging. Highly-sensitive fluorescent probes are required for high-quality fluorescence imaging, and the rapid development of nanotechnology has led to the emergence of organic dyes with excellent fluorescent properties. Among them, organic fluorescent probes with the advantages of high safety, good biocompatibility, and high optical stability, are more favorable than inorganic fluorescent probes. Therefore, NIR fluorescence imaging assisted with organic fluorescent probes can provide more structural and dynamic information of biological samples to the researchers, which becomes a hot spot in the interdisciplinary research field of optics, chemistry and biomedicine. This review summarizes the application of NIR organic fluorescent probes in cervical cancer imaging. Several typical organic fluorescent probes (such as indocyanine green, heptamethine cyanine dye, rhodamine and polymer fluorescent nanoparticles) assisted NIR fluorescence imaging and their applications in cervical cancer diagnosis were introduced, and the future development and application of these techniques were discussed.

Braquiterapia adaptativa guiada por resonancia magnética para el cáncer cervical localmente avanzado: experiencia del Hospital Carlos Van Buren / MRI-guided adaptive brachytherapy for locally advanced cervical cancer: experience at Carlos Van Buren Hospital

Introducción y objetivos: El tratamiento estándar para pacientes con cáncer cervical localmente avanzado (CCLA) se basa en radioterapia externa y quimioterapia concomitante seguida de braquiterapia adaptativa guiada por imágenes (BTAGI). El objetivo de este estudio fue describir los resultados del protocolo de BTAGI de resonancia magnética del Servicio de Oncología del Hospital Carlos Van Buren. Métodos: En pacientes con CCLA tratadas con Radioquimioterapia concomitante seguida de BTAGI de resonancia magnética se evaluó la reducción tumoral, parámetros dosimétricos y la toxicidad aguda. Resultados: Se evaluó la reducción tumoral entre el diagnóstico y el momento de la braquiterapia en 34 pacientes. Todas las pacientes completaron el tratamiento de radioterapia externa. Veinticuatro pacientes recibieron 3 sesiones de braquiterapia. Dosis equivalentes totales > 80 Gy se logro en todos los pacientes. Doce pacientes presentaron reducción del volumen tumoral mayor al 70%. La mediana de las dosis equivalentes totales prescritas al D2cc de vejiga fue 73.9 Gy, al recto 65.6 Gy y al intestino fue de 69.1 Gy. Una paciente presento toxicidad gastrointestinal grado ≥ 3. No hubo diferencias estadísticamente significativas al comparar pacientes que recibieron dosis equivalentes totales desde los 85 Gy con las que recibieron menor dosis respecto a toxicidad gastrointestinal (p=0.33) y genitourinaria (p=0.97). Conclusión: La braquiterapia adaptativa guiada por resonancia magnética se puede realizar en el sistema público de salud y cumplir con las recomendaciones internacionales requeridas para el tratamiento estándar del CCLA.

Introduction and purpose: External beam radiation therapy with concomitant chemotherapy followed by adaptive image-guided brachytherapy (IGABT) is the standard of care for patients with locally advanced cervical cancer (LACC). The purpose of this study was to describe the local outcomes of the magnetic resonance IGABT protocol at the radiation oncology department of the Carlos Van Buren Hospital. Methods: Tumor reduction, dosimetric parameters and acute toxicity were evaluated in patients with LACC treated with concomitant radiochemotherapy followed by magnetic resonance IGABT. Results: Tumor reduction between diagnosis and brachytherapy was evaluated in 34 patients. All patients completed external radiation therapy treatment. Twenty-four patients received 3 sessions of brachytherapy. All patients received a total equivalent dose > 80 Gy. Twelve patients showed a tumor volume reduction greater than 70%. The median total equivalent dose prescribed to the bladder D2cc was 73.9 Gy, the rectum 65.6 Gy, and the intestine 69.1 Gy. One patient presented grade ≥ 3 gastrointestinal toxicity. No statistically significant differences were found when comparing patients who received total equivalent doses larger than 85 Gy with those who received lower doses regarding gastrointestinal (p = 0.33) and genitourinary (p = 0.97) toxicity. Conclusion: MRI-guided adaptive brachytherapy can be performed in the public health system and achieve the international recommendations required as standard of care treatment of LACC.

Automated Pre-delineation of CTV in Patients with Cervical Cancer Using Dense V-Net / 中国医疗器械杂志

We use a dense and fully connected convolutional network with good feature learning in small samples, to automatically pre-deline CTV of cervical cancer patients based on CT images and evaluate the effect. The CT data of stage IB and IIA postoperative cervical cancer with similar delineation scope were selected to be used to evaluate the pre-sketching accuracy from three aspects:sketching similarity, sketching offset and sketching volume difference. It has been proved that the 8 most representative parameters are superior to those with single network and reported internationally before. Dense V-Net can accurately predict CTV pre-delineation of cervical cancer patients, which can be used clinically after simple modification by doctors.

Cervical cancer - staging and restaging with 18F-FDG PET/CT

The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

Hallazgo de Tumor Maligno/Premaligno Insospechado en Estudios 18 F-FDG PET/TC en Pacientes Oncológicos: Incidental Malignant/Premalignant Tumor Detection in Oncological Patients / 18 f-fdg pet/ct

Objetivo Determinar la frecuencia y el tipo de tumor maligno/premaligno insospechado como hallazgo en estudios 18 F-FDG PET/TC en pacientes oncológicos. Material y Métodos Se revisaron retrospectivamente (de enero de 2014 a marzo de 2017), informes de estudios 18 F-FDG PET/TC de pacientes oncológicos, identificando aquellos pacientes con hallazgo de lesión sospechosa de otro tumor maligno como hallazgo incidental. La información fue obtenida a partir de determinadas "palabras clave" en la base de datos del Centro. Los hallazgos se confirmaron mediante histopatología y/o seguimiento clínico y paraclínico de como mínimo seis meses. Resultados De 4.086 pacientes oncológicos estudiados con 18 F-FDG PET/TC, se encontró lesión sospechosa de otro tumor maligno en 130 (3,2%), de los cuales 72 eran mujeres y 58 hombres, con edad media de 61 años. Los tumores primarios más frecuentes (aquellos que motivaron el pedido del examen PET/CT inicialmente), fueron de mama (n = 27), pulmón (n = 27) y colo-recto (n = 20). Se confirmaron por histopatología 49 (1,2%) nuevos tumores malignos/premalignos y dos lesiones metastásicas. La localización del segundo tumor primario correspondió a: colon (n = 18), pulmón (n = 6), mama (n = 6), linfoma (n = 3), ovario (n = 2), endometrio/cuello uterino (n = 2), tiroides (n = 2) y otros (n = 10). Resultaron 28 hallazgos falsos positivos, 31 pacientes no se estudiaron por progresión lesional y 20 pacientes se perdieron de seguimiento. Discusión La prevalencia de neoplasia primaria maligna múltiple (NPMM) es variable entre 0,7 y 11,7%. En nuestra serie, se encontró lesión sospechosa de segundo tumor en 130 casos (3,2%), de los cuales se confirmaron 49 segundos tumores (1,2%), similar a Conclusiones La tasa de detección de tumor maligno insospechado confirmado histológicamente fue de 1,2%. Todo hallazgo incidental sospechoso de malignidad en 18 F-FDG PET/TC debe ser estudiado, ya que puede corresponder a un segundo tumor maligno no sospechado con posibilidad de tratamiento curativo.

Purpose To determine the frequency and type of unexpected malignant/ premalignant tumor as a finding in 18 F-FDG PET/CT studies in oncological patients. Material and Methods Reports of 18 F-FDG PET/CT studies of oncological patients were reviewed retrospectively (from January 2014 to March 2017), with the finding of suspicious lesion of another malignant tumor. The information was obtained from certain "keywords" in the Center's database. The findings were confirmed by histopathology when possible and with clinical and paraclinical follow-up for at least six months. Results Of 4086 oncological patients, studied with 18 F-FDG PET/CT, a suspicious lesion of another malignant tumor was found in 130 (3.2%), 72 female and 58 male sex, average age 61 years. The most frequent primary tumors were: breast (n = 27), lung (n = 27) and colo-rectum (n = 20). 49 (1.2%) new malignant/premalignant tumors and two metastatic lesions were confirmed by histopathology. The location of the second primary tumor was: colon (n = 18), lung (n = 6), breast (n = 6), lymphoma (n = 3), ovary (n = 2), endometrium/cervix (n = 2), thyroid (n = 2) and others (n = 10). There were 28 false positive findings, 31 patients were not studied for progression and 20 patients were lost to follow-up. Discussion The prevalence of multiple malignant primary neoplasia (MMPN) is variable between 0.7 and 11.7%. In our series, a suspicious second tumor lesion was found in 130 cases (3.2%), of which 49 second tumors (1.2%) were confirmed, similar to that reported by other authors. Conclusions The detection rate of unsuspected malignant tumor was 1.2%, coincident with the literature. Any incidental finding suspicious of malignancy in 18 F-FDG PET/CT should be studied since in most cases it corresponds to early diagnosis with the possibility of curative treatment.

Câncer do colo do útero na gravidez / Cancer of the cervix in pregnancy

O câncer do colo do útero é o câncer mais comum na gravidez, com uma estimativa de 1 a 12 casos por 10.000 gestações. Com a melhora do rastreio do câncer do colo do útero e uma tendência feminina de engravidar em idade mais avançada, observa-se que cerca de 43% das pacientes diagnosticadas com câncer do colo do útero têm menos de 45 anos e 20% a 28% são menores de 40 anos. O diagnóstico e o tratamento da doença na gravidez são difíceis e desafiadores, pois geram angústia para a gestante, sua família e os profissionais de saúde. Novos estudos destacam que a preservação da fertilidade e a qualidade de vida estão se tornando preocupações cada vez mais importantes de mulheres jovens com câncer e que os procedimentos cirúrgicos devem ser menos invasivos. O comitê de oncologia da FIGO revisou o sistema de estadiamento do câncer do colo do útero. Este artigo discute o diagnóstico e tratamento do câncer do colo do útero com base no estágio da doença, incluindo atenção a questões de fertilidade e qualidade de vida.(AU)

Cervical cancer is the most common cancer in pregnancy, with an estimated 1-12 cases per 10,000 pregnancies. With improved cervical cancer screening and a tendency to become pregnant at a later age, it is noted that about 43% of patients diagnosed with cervical cancer are younger than 45 and 20-28% are younger than 40 years. Diagnosis and treatment of the disease in pregnancy are difficult and challenging, as they create distress for pregnant women, their families and health professionals. New studies highlight that preserving fertility and quality of life are becoming increasingly important concerns for young women with cancer and that surgical procedures should be less invasive. The FIGO oncology committee reviewed the staging system for cervical cancer. This article discusses the diagnosis and treatment of cervical cancer based on the stage of the disease, including attention to issues of fertility and quality of life.(AU)

Correlación cito-colpo-histológica en lesiones premalignas del cuello uterino en el Hospital Básico Píllaro en Ecuador / Cito-Colpo-Histological Correlation in Premalignant Cervical Lesions

Introducción: el cáncer cervicouterino es una de las amenazas más graves para la vida de las mujeres. Actualmente en el mundo lo padecen más de un millón de ellas. En Ecuador, ocupa el segundo lugar en incidencia y causa 1,2 por ciento de muertes anuales en el país. Su detección oportuna es posible gracias a la citología cervicovaginal que contribuye eficazmente a detectar lesiones precancerosas y disminuir significativamente el carcinoma del cuello uterino. El estudio de la paciente se complementa con colposcopia y toma de biopsia para aumentar la certeza diagnóstica. En algunos casos, no se ha observado una buena correlación diagnóstica. Objetivo: determinar la relación citocolpohistológica en pacientes atendidas con Papanicolaou alterado en consulta de Patología del Tracto Genital Inferior. Métodos: se revisaron 82 historias clínicas de pacientes atendidas con Papanicolaou alterado en la consulta de Patología del Tracto Genital Inferior en el Hospital Básico Píllaro de Ecuador desde abril de 2015 hasta abril de 2016. Resultados: del total de pacientes, 32,9 por ciento tenían entre 30 y 39 años de edad; 90,2 por ciento iniciaron sus relaciones sexuales durante la adolescencia. De ellas, 89 por ciento tuvo entre una y cinco parejas sexuales; 59,7 por ciento tuvo entre uno y tres partos. Existió un 21,4 por ciento de correlación cito-colposcópica en el diagnóstico de las lesiones intraepiteliales de bajo grado. La relación colpo-histológica mostró un 87,5 por ciento de coincidencias en las lesiones intraepiteliales de bajo grado y en las lesiones intraepiteliales de alto grado un 71,4 por ciento. Conclusiones: el inicio precoz de la actividad sexual, las múltiples parejas sexuales y la multiparidad continúan resaltando en la aparición de las lesiones premalignas del cuello uterino(AU)

Introduction: Cervical cancer is one of the most serious threats to the lives of women. In the world today, more than a million of them suffer from it. In Ecuador, it ranks second in incidence and causes 1.2 percent of annual deaths in the country. Its timely detection is possible thanks to cervicovaginal cytology that contributes effectively to detecting precancerous lesions and significantly decreasing carcinoma of the cervix. The patient's study is complemented by colposcopy and biopsy to increase diagnostic certainty even when good diagnostic correlation has not been observed in some cases. Objective: Determine the cyto-colpo-histological relationship in patients treated due to altered Papanicolaou, in consultation of Pathology of the Lower Genital Tract in Píllaro Basic Hospital. Ecuador. Methods: In the present study, we reviewed 82 clinical records of patients treated with altered Papanicolaou in the Lower Genital Tract Pathology consultation at the Píllaro Basic Hospital, Ecuador from April 2015 to April 2016. Results: 32.9 percent of patients aged 30 to 39 years; 90.2 percent started sexual intercourse throughout adolescence. 89 percent had one to five sexual partners. 59.7 percent had one to three deliveries. There was 21.4 percent cyto-colposcopic correlation in the diagnosis of low-grade intraepithelial lesions (LSIL). The colpo-histological relationship showed 87.5 percent of coincidences in the LSIL and 71.4 percent. showed high-grade intraepithelial lesions (HSIL)(AU)

Synchronous gynecologic cancer and the use of imaging for diagnosis / Câncer ginecológico sincrônico e o uso da imagem para seu diagnóstico

Summary Endometrial and cervical cancers are the most prevalent gynecologic neoplasms. While endometrial cancer occurs in older women, cervical cancer is more prevalente in young subjects. The most common clinical manifestation in these two gynecological cancers is vaginal bleeding. In the first case, diagnosis is made based on histological and imaging evaluation of the endometrium, while cervical cancers are diagnosed clinically, according to the International Federation of Gynecology and Obstetrics (FIGO). The authors present a case of synchronous gynecological cancer of the endometrium and cervix diagnosed during staging on MRI and confirmed by histological analysis of the surgical specimen.

Resumo Os cânceres de endométrio e cervical são as neoplasias ginecológicas mais prevalentes. Enquanto o primeiro ocorre em mulheres mais velhas, o segundo é mais prevalente em mulheres jovens. A manifestação clínica mais comum nestas duas neoplasias ginecológicas é o sangramento vaginal. O diagnóstico do câncer de endométrio é feito a partir da avaliação histológica do endométrio e da avaliação por imagem, enquanto o câncer cervical é diagnosticado clinicamente, de acordo com a Federação Internacional de Ginecologia e Obstetrícia (FIGO). Apresentamos um caso de câncer ginecológico sincrônico de endométrio e cervical diagnosticado durante estadiamento por ressonância magnética e confirmado pela análise histológica da peça cirúrgica.

Cáncer de cérvix en gestantes de la Isla de la Juventud (2014) / Cervical cancer in pregnant women of the Isle of Youth (2014)

Introducción: el cáncer es una rara condición durante el embarazo. Debido a la tendencia general de posponer la etapa reproductiva a edades superiores y al efecto que sobre este fenómeno tienen las técnicas de reproducción asistida; la coincidencia de cáncer y embarazo se ha incrementado. Aunque el carcinoma in situ constituya una lesión temprana, la atipicidad celular en todo el epitelio denota una gran preocupación para los facultativos del campo de la Ginecoobstetricia. Objetivo: presentar la incidencia de cáncer de cérvix durante un año en gestantes en Isla de la Juventud. Métodos: se presentan detalladamente 6 gestantes que fueron diagnosticadas con cáncer de cérvix en el año 2014. Resultados: hace más de una década en la Isla de la Juventud se ha identificado al cáncer como uno de sus principales problemas de salud, y dentro de este, la localización cervical con crecientes valores de incidencia y un desplazamiento a grupos poblaciones más jóvenes. Conclusiones: en el territorio pinero no se había documentado con anterioridad el diagnóstico de estas malignidades en una gestante, lo que hace novedosa e interesante la información que se presenta en este artículo sobre el diagnóstico y manejo terapéutico de una pequeña serie de seis casos atendidos durante el año 2014(AU)

Introduction: Cancer is a rare condition during pregnancy. Due to the general tendency to delay the reproductive stage at advanced ages and the effect that assisted reproduction techniques have on this phenomenon; the coincidence of cancer and pregnancy is increased. Although the in situ carcinoma constitutes an early injury, unusualness cell throughout the epithelium denotes a major concern for physicians in the field of Gynecology and Obstetrics. Objective: Present the incidence of cervical cancer during a year in pregnant women in Isla de la Juventud. Methods: Details of six pregnant women, who were diagnosed with cervical cancer in 2014, are presented. Results: For over a decade in the Isle of Youth, cancer has been identified as one of its major health problems, and within this, the cervical location; with increasing values of incidence and a shift to younger populations groups. Conclusions: The diagnosis of these malignancies in a pregnant woman has not been discussed earlier in the Isle of Youth territory, so information presented in this article on the diagnosis and therapeutic management of a small series of six cases treated during 2014 is new and interesting(AU)

Advances in diagnosis and treatment of metastatic cervical cancer / 부인종양

Cervical cancer is one of the most common cancers in women worldwide. The outcome of patients with metastatic cervical cancer is poor. We reviewed the relevant literature concerning the treatment and diagnosis of metastatic cervical cancer. There are two types of metastasis related to different treatments and survival rates: hematogenous metastasis and lymphatic metastasis. Patients with hematogenous metastasis have a higher risk of death than those with lymphatic metastasis. In terms of diagnosis, fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) and PET-computed tomography are effective tools for the evaluation of distant metastasis. Concurrent chemoradiotherapy and subsequent chemotherapy are well-tolerated and efficient for lymphatic metastasis. As for lung metastasis, chemotherapy and/or surgery are valuable treatments for resistant, recurrent metastatic cervical cancer and chemoradiotherapy may be the optimal choice for stage IVB cervical cancer. Chemotherapy and bone irradiation are promising for bone metastasis. A better survival is achieved with multimodal therapy. Craniotomy or stereotactic radiosurgery is an optimal choice combined with radiotherapy for solitary brain metastases. Chemotherapy and palliative brain radiation may be considered for multiple brain metastases and other organ metastases.

Advances in diagnosis and treatment of metastatic cervical cancer / 부인종양

Cervical cancer is one of the most common cancers in women worldwide. The outcome of patients with metastatic cervical cancer is poor. We reviewed the relevant literature concerning the treatment and diagnosis of metastatic cervical cancer. There are two types of metastasis related to different treatments and survival rates: hematogenous metastasis and lymphatic metastasis. Patients with hematogenous metastasis have a higher risk of death than those with lymphatic metastasis. In terms of diagnosis, fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) and PET-computed tomography are effective tools for the evaluation of distant metastasis. Concurrent chemoradiotherapy and subsequent chemotherapy are well-tolerated and efficient for lymphatic metastasis. As for lung metastasis, chemotherapy and/or surgery are valuable treatments for resistant, recurrent metastatic cervical cancer and chemoradiotherapy may be the optimal choice for stage IVB cervical cancer. Chemotherapy and bone irradiation are promising for bone metastasis. A better survival is achieved with multimodal therapy. Craniotomy or stereotactic radiosurgery is an optimal choice combined with radiotherapy for solitary brain metastases. Chemotherapy and palliative brain radiation may be considered for multiple brain metastases and other organ metastases.

We should not settle for low-level evidence but should always use the best available evidence / 부인종양

No abstract available.

Shall we settle for low-level evidence? / 부인종양

No abstract available.

Utilidad del PET--FDG en patología gineco-oncológica / Usefulness of PET--FDG in gynecological-oncological pathology

El PET-FDG es un estudio de imágenes de cuerpo entero que evalúa el metabolismo glucídico celular. Su mayor utilidad es en oncología tanto en adultos como en niños. Permite distinguir tumores malignos de benignos, seleccionar los sitios de biopsia, etapificar las neoplasias, determinar la respuesta al tratamiento y distinguir entre cicatriz y enfermedad residual post tratamiento. Diversos estudios han concluido que el PET-FDG es un examen útil en el manejo de la patología gineco-oncológica, destacando en cáncer de endometrio, cérvico uterino y ovárico. En este trabajo, se revisan las indicaciones de la técnica en las diversas patologías ginecológicas neoplásicas y su rendimiento. Asimismo, se presenta la experiencia chilena inicial realizada en el Hospital Militar de Santiago con equipo PET dedicado, donde se han estudiado más de 1.500 pacientes en su gran mayoría oncológicos.

FDG-PET is a whole body scan that evaluates glucose cell metabolism. Its main utility is in adult and children oncology. PET scan is useful differentiating benign from malignant neoplasm, selecting the site for biopsy, staging of the malignancy, evaluating response to therapy and distinguishing scar from residual neoplasm. Different studies have concluded that FDG-PET is a useful study in the gyneco-oncological management, especially in endometrial, cervical and ovarian cancer. This work reviews the principal indications of PET in this pathology and also the initial Chilean experience at the Military Hospital of Santiago with a dedicated PET, where we have studied more than 1,500 cases, most of them in cancer patients.

Diagnosis of Recurrent Uterine Cervical Cancer: Computed Tomography versus Positron Emission Tomography

OBJECTIVE: To determine the accuracy of CT and positron emission tomography (PET) in the diagnosis of recurrent uterine cervical cancer. MATERIALS AND METHODS: Imaging findings of CT and PET in 36 patients (mean age, 53 years) in whom recurrent uterine cervical cancer was suspected were analyzed retrospectively. Between October 1997 and May 1998, they had undergone surgery and/or radiation therapy. Tumor recurrence was confirmed by pathologic examination or follow-up studies. RESULTS: In detecting recurrent uterine cervical cancer, the sensitivity, specificity, and accuracy of CT were 77.8%, 83.3%, and 80.5%, respectively, while for PET, the corresponding figures were 100%, 94.4%, and 97.2%. The Chisquare test revealed no significant difference in specificity (p = .2888), but significant differences in sensitivity (p = .0339) and accuracy (p = .0244). CONCLUSION: PET proved to be a reliable screening method for detecting recurrent uterine cervical cancer, but to determine the anatomical localization of recurrent tumors, and thus decide an adequate treatment plan, CT was eventually needed.